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Home > Products >  Topiroxostat

Topiroxostat CAS NO.577778-58-6

  • Min.Order: 10 Gram
  • Payment Terms: T/T,Western Union,MoneyGram
  • Product Details

Keywords

  • FYX-051
  • DMSO
  • xanthine oxidoreductase

Quick Details

  • ProName: Topiroxostat
  • CasNo: 577778-58-6
  • Molecular Formula: C13H8N6
  • Appearance: light white or white powder
  • Application: Pharmaceutical Intermediates / Active ...
  • DeliveryTime: 3 working days
  • PackAge: foil bags, drums or bottles
  • Port: CMP
  • ProductionCapacity: 100 Metric Ton/Day
  • Purity: 99%
  • Storage: Shading, sealed, dry place.
  • Transportation: 1) By air - DHL, TNT,FEDEX,EMS...ETC. ...
  • LimitNum: 10 Gram

Superiority

price, service, company and transport advantage:


	
1. best service, high quality and reasonable price.
2. it's customers' right to choose the package (ems, dhl, fedex, ups).
3. it's customers' right to choose the packing way for his produccts from many recent effective packing way.
4. specials are possible when client's order is big enough, including the discount policy.
5. our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time.
6. we can help our regular clients to suggest some vials factories which produce different size vials(2ml, 5ml, 7ml, 10ml, 20ml...), hoping can bring you convenience if you need these vials.
7. return policy: we promise we will return your money if our product don't have effect.

delivery: various shipping methods such as fedeex, ems, hkems, tnt, dhl, ups

supplier: jilin tely imp & exp co.,ltd

Details

JILIN TELY IMP & EXP CO.,LTD
 
CAS NO. 577778-58-6
1. Product Name : Topiroxostat 
 
2. Another name: FYX-051
 
3. CasNo: 577778-58-6
 
4. M.Wt: 248.24
 
5. Formula: C13H8N6
 
6. Solubility: DMSO
 
7. Appearance: light white or white powder
 
8. Application: Use as the pharma
 
9. Purity: 99%
 
10. Topiroxostat(FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM.
IC50 value: 5.3 nM [1]
 
11. Target: xanthine oxidoreductase
 
in vitro: Steady-state kinetics study showed that FYX-051 initially behaved as a competitive-type inhibitor with a K(i) value of 5.7 × 10(-9) M, then after a few minutes it formed a tight complex with XOR via a Mo-oxygen-carbon atom covalent linkage, as reported previously [3].
 
in vivo: FYX-051 exhibited a weak CYP3A4-inhibitory activity (18.6%); its Cmax and bioavailability were as high as 4.62 μg/mL (3 mg/kg) and 69.6%, respectively. Moreover, the t1/2 value of 39 was greater (19.7 h) than that of compound 2 (0.97 h) [1]. In the mechanistic study by 52-week oral treatment with topiroxostat at 3 mg/kg to F344 male rats, with and without citrate, simple and papillary transitional cell hyperplasias of the urinary bladder epithelium were observed in 5/17 in the topiroxostat-alone treatment group, along with xanthine-induced nephropathy, in contrast to neither xanthine crystals nor lesions in urinary organs by co-treatment group with citrate [2].
 
Product Detail
 
Minimum Order Qty.
10 Gram to 1000 Kilograms according to different product and different price
Supply Ability
2000 MT/Month
Storage
store in cool, dry, ventilated place 20℃
Delivery Time
3 business days after payment
Payment Term
TT,western union,Paypal,MoneyGram
Package
200 kg/drum , 25 KG/drum, 25 KG/bag, 500g/foil bag,10g/foil bag,10g/bottle...or customized
Transportation
by Sea, air and express

 

Jilin Tely Focus on:

 

1.APIs / Pharmaceutical Intermediates

2.Additive

3.Reagent

4.agrochemicals

5.Veterinary

6.Organic chemicals

 

Company Information

 

    Jilin Tely Imp & Exp Co., Ltd. is located in Changchun, a national historical and cultural city, Jilin Province, China. It covers an area of 22,000 square meters, construction area of 6,000 square meters. We have our own import and export rights. Main Supply: fine chemicals, pharmaceutical and pesticide intermediates.

    Over the years, the company adhere to market-oriented, technology and development, quality of life for the purpose. Strengthening enterprise management, has a high quality, the ability to develop strong and rich experience in the production of professional and technical teams. Production of advanced technology, sophisticated equipment, means of improving detection.

    Our products are exported to the United States, European Union, Southeast Asia and other countries and regions. Users both here and abroad and has established long-term and stable supplier relations, occupies a stable market share and to maintain sustained growth. And with domestic and foreign universities, research institutes and some well-known companies have extensive cooperation and close ties.

    We follow the "quality and integrity" business philosophy, For Chinese and foreign customers to provide quality products and services in order to do long-term win-win business, and seek common development. We sincerely welcome friends from all over the world to exchange and cooperation!

 

Our Factory

 

 

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